Muscle O2 deficit during hypoxia and two levels of O2 demand.
J Appl Physiol (1985)
; 62(4): 1384-91, 1987 Apr.
Article
em En
| MEDLINE
| ID: mdl-3597213
ABSTRACT
We have examined the relative deficits in tension development and O2 uptake in contracting skeletal muscle during severe hypoxic hypoxia. Anesthetized mongrel dogs were ventilated to maintain an end-tidal PCO2 between 35 and 40 Torr. Venous outflow from the gastrocnemius muscle was measured using an electromagnetic flow probe. The tendon was cut and attached to a strain gauge. The muscle was stimulated to contract isometrically at 2 or 4 Hz for 20 min. Hypoxia (9% O2 in N2) was then imposed for 30 min, followed by 30 min of normoxia. Blood flow first increased in proportion to the contraction frequency and then increased further a similar amount in both groups during hypoxia. O2 extraction and blood flow reached maximal levels during hypoxia in the 2-Hz group. The further O2 deficit that was accumulated during 4 Hz and hypoxia was, therefore, a result of the greater discrepancy between O2 supply and demand. O2 uptake decreased more in hypoxia than did developed tension. These results are best explained by ATP supplementation from nonaerobic energy sources that was promoted by the free-flow condition of hypoxic hypoxia.
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Base de dados:
MEDLINE
Assunto principal:
Consumo de Oxigênio
/
Hipóxia
/
Músculos
Limite:
Animals
Idioma:
En
Ano de publicação:
1987
Tipo de documento:
Article