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Orexin 2 receptor-selective agonist danavorexton improves narcolepsy phenotype in a mouse model and in human patients.
Evans, Rebecca; Kimura, Haruhide; Alexander, Robert; Davies, Ceri H; Faessel, Hélène; Hartman, Deborah S; Ishikawa, Takashi; Ratti, Emiliangelo; Shimizu, Kohei; Suzuki, Motohisa; Tanaka, Shinichiro; Yukitake, Hiroshi; Dauvilliers, Yves; Mignot, Emmanuel.
Afiliação
  • Evans R; Neuroscience Therapeutic Area Unit, Takeda Pharmaceuticals International Co., Cambridge, MA 02139.
  • Kimura H; Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, 251-8555, Japan.
  • Alexander R; Neuroscience Therapeutic Area Unit, Takeda Pharmaceuticals International Co., Cambridge, MA 02139.
  • Davies CH; Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, 251-8555, Japan.
  • Faessel H; Neuroscience Therapeutic Area Unit, Takeda Pharmaceuticals International Co., Cambridge, MA 02139.
  • Hartman DS; Neuroscience Therapeutic Area Unit, Takeda Pharmaceuticals International Co., Cambridge, MA 02139.
  • Ishikawa T; Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, 251-8555, Japan.
  • Ratti E; Neuroscience Therapeutic Area Unit, Takeda Pharmaceuticals International Co., Cambridge, MA 02139.
  • Shimizu K; Takeda Development Center Japan, Takeda Pharmaceutical Company Limited, Osaka, 532-8686, Japan.
  • Suzuki M; Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, 251-8555, Japan.
  • Tanaka S; Takeda Development Center Japan, Takeda Pharmaceutical Company Limited, Osaka, 532-8686, Japan.
  • Yukitake H; Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, 251-8555, Japan.
  • Dauvilliers Y; National Reference Network for Narcolepsy, Sleep-Wake Disorders Center, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, INM, INSERM, University of Montpellier, Montpellier, 34295, France.
  • Mignot E; Stanford Department of Psychiatry and Behavioral Medicine, Center for Sleep Sciences and Medicine, Stanford University Medical School, Palo Alto, CA 94304.
Proc Natl Acad Sci U S A ; 119(35): e2207531119, 2022 08 30.
Article em En | MEDLINE | ID: mdl-35994639
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Orexina / Estimulantes do Sistema Nervoso Central / Narcolepsia Tipo de estudo: Prognostic_studies Limite: Adult / Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Orexina / Estimulantes do Sistema Nervoso Central / Narcolepsia Tipo de estudo: Prognostic_studies Limite: Adult / Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article