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Topical Reappraisal of Molecular Pharmacological Approaches to Endothelial Dysfunction in Diabetes Mellitus Angiopathy.
Munteanu, Constantin; Rotariu, Mariana; Turnea, Marius-Alexandru; Anghelescu, Aurelian; Albadi, Irina; Dogaru, Gabriela; Silișteanu, Sînziana Calina; Ionescu, Elena Valentina; Firan, Florentina Carmen; Ionescu, Anca Mirela; Oprea, Carmen; Onose, Gelu.
Afiliação
  • Munteanu C; Faculty of Medical Bioengineering, University of Medicine and Pharmacy "Grigore T. Popa" Iași, 700454 Iași, Romania.
  • Rotariu M; Neuromuscular Rehabilitation Division, Teaching Emergency Hospital "Bagdasar-Arseni", 041915 Bucharest, Romania.
  • Turnea MA; Faculty of Medical Bioengineering, University of Medicine and Pharmacy "Grigore T. Popa" Iași, 700454 Iași, Romania.
  • Anghelescu A; Faculty of Medical Bioengineering, University of Medicine and Pharmacy "Grigore T. Popa" Iași, 700454 Iași, Romania.
  • Albadi I; Neuromuscular Rehabilitation Division, Teaching Emergency Hospital "Bagdasar-Arseni", 041915 Bucharest, Romania.
  • Dogaru G; Faculty of Midwives and Nursing, University of Medicine and Pharmacy "Carol Davila", 020022 Bucharest, Romania.
  • Silișteanu SC; Faculty of Medicine, Ovidius University of Constanta, 900470 Constanta, Romania.
  • Ionescu EV; Teaching Emergency County Hospital "Sf. Apostol Andrei", 900591 Constanta, Romania.
  • Firan FC; Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
  • Ionescu AM; Clinical Rehabilitation Hospital, 400437 Cluj-Napoca, Romania.
  • Oprea C; Faculty of Medicine and Biological Sciences, "Stefan cel Mare" University of Suceava, 720229 Suceava, Romania.
  • Onose G; Faculty of Medicine, Ovidius University of Constanta, 900470 Constanta, Romania.
Curr Issues Mol Biol ; 44(8): 3378-3397, 2022 Jul 28.
Article em En | MEDLINE | ID: mdl-36005129
Diabetes mellitus (DM) is a frequent medical problem, affecting more than 4% of the population in most countries. In the context of diabetes, the vascular endothelium can play a crucial pathophysiological role. If a healthy endothelium-which is a dynamic endocrine organ with autocrine and paracrine activity-regulates vascular tone and permeability and assures a proper balance between coagulation and fibrinolysis, and vasodilation and vasoconstriction, then, in contrast, a dysfunctional endothelium has received increasing attention as a potential contributor to the pathogenesis of vascular disease in diabetes. Hyperglycemia is indicated to be the major causative factor in the development of endothelial dysfunction. Furthermore, many shreds of evidence suggest that the progression of insulin resistance in type 2 diabetes is parallel to the advancement of endothelial dysfunction in atherosclerosis. To present the state-of-the-art data regarding endothelial dysfunction in diabetic micro- and macroangiopathy, we constructed this literature review based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We interrogated five medical databases: Elsevier, PubMed, PMC, PEDro, and ISI Web of Science.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article