Identification of necroptosis-related signature and tumor microenvironment infiltration characteristics in lung adenocarcinoma.
Lung Cancer
; 172: 75-85, 2022 10.
Article
em En
| MEDLINE
| ID: mdl-36027854
ABSTRACT
OBJECTIVES:
Lung cancer remains the most common cancer and the leading cause of cancer deaths. However, the potential roles of necroptosis-related signature and tumor microenvironment (TME) in the lung adenocarcinoma (LUAD) still unknown. MATERIALS ANDMETHODS:
Expression data and clinical information were obtained from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database. In the TCGA dataset, necroptosis phenotype-related differentially expressed genes (DEGs) were identified. A necroticscore score was developed and validated by integrating GEO-meta datasets. The clinical value of the risk score was further evaluated using Kaplan-Meier and immunotherapeutic cohort (IMvigor210 cohort).RESULTS:
Three necroptosis-related patterns and distinct necroptosis-related gene cluster were identified based on the abnormal expression of 14 necroptosis regulators. The necroptosis genomic phenotypes were obtained based on 117 necroptosis phenotype-related DEGs. A necroticscore were constructed to evaluate necroptosis pattern of each patient. Low necroticscore was linked with decreased immune check-point expression, enhanced immune check-point inhibitor response, and better clinical benefits.CONCLUSION:
This study suggested that the crucial roles of necroptosis-related regulators in modeling the heterogeneity of TME characteristics. Thus, assessing necroptosis patterns provided us with a deeper understanding of TME and might guide the clinical immunotherapy treatment of lung cancer.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Adenocarcinoma de Pulmão
/
Neoplasias Pulmonares
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article