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IMI2-PainCare-BioPain-RCT2 protocol: a randomized, double-blind, placebo-controlled, crossover, multicenter trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity.
Leone, Caterina; Di Stefano, Giulia; Di Pietro, Giuseppe; Bloms-Funke, Petra; Boesl, Irmgard; Caspani, Ombretta; Chapman, Sonya C; Finnerup, Nanna Brix; Garcia-Larrea, Luis; Li, Tom; Goetz, Marcus; Mouraux, André; Pelz, Bernhard; Pogatzki-Zahn, Esther; Schilder, Andreas; Schnetter, Erik; Schubart, Karin; Tracey, Irene; Troconiz, Inaki F; Van Niel, Hans; Hernandez, Jose Miguel Vela; Vincent, Katy; Vollert, Jan; Wanigasekera, Vishvarani; Wittayer, Matthias; Phillips, Keith G; Truini, Andrea; Treede, Rolf-Detlef.
Afiliação
  • Leone C; Department of Human Neuroscience, Sapienza University, Rome, Italy. caterinamaria.leone@gmail.com.
  • Di Stefano G; Department of Human Neuroscience, Sapienza University, Rome, Italy.
  • Di Pietro G; Department of Human Neuroscience, Sapienza University, Rome, Italy.
  • Bloms-Funke P; Translational Science & Intelligence, Grünenthal GmbH, Aachen, Germany.
  • Boesl I; Clinical Science Development, Grünenthal GmbH, Aachen, Germany.
  • Caspani O; Department of Neurophysiology, Mannheim Center for Translational Neurosciences (MCTN), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • Chapman SC; Neuroscience Next Generation Therapeutics, Eli Lilly and Company, Lilly Innovation Center, Cambridge, MA, USA.
  • Finnerup NB; Eli Lilly and Company, Arlington Square, Bracknell, UK.
  • Garcia-Larrea L; Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
  • Li T; Lyon Neurosciences Center Research Unit Inserm U 1028, Pierre Wertheimer Hospital, Hospices Civils de Lyon, Lyon 1 University, Lyon, France.
  • Goetz M; Teva Pharmaceutical Industries Ltd., Petah Tikva, Israel.
  • Mouraux A; MRC Systems GmbH, Heidelberg, Germany.
  • Pelz B; Institute of Neuroscience (IoNS), UCLouvain, Brussels, Belgium.
  • Pogatzki-Zahn E; MRC Systems GmbH, Heidelberg, Germany.
  • Schilder A; Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.
  • Schnetter E; Department of Neurophysiology, Mannheim Center for Translational Neurosciences (MCTN), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • Schubart K; University Computing Centre, University of Heidelberg, Heidelberg, Germany.
  • Tracey I; ConsulTech GmbH, Berlin, Germany.
  • Troconiz IF; Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
  • Van Niel H; Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.
  • Hernandez JMV; Mature Products Development, Grünenthal GmbH, Aachen, Germany.
  • Vincent K; Welab Barcelona, Barcelona, Spain.
  • Vollert J; Drug Discovery & Preclinical Development, ESTEVE Pharmaceuticals, Barcelona, Spain.
  • Wanigasekera V; Nuffield Department of Women's and Reproductive Health (NDWRH), University of Oxford, Oxford, UK.
  • Wittayer M; Department of Neurophysiology, Mannheim Center for Translational Neurosciences (MCTN), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • Phillips KG; Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.
  • Truini A; Pain Research, Department of Surgery and Cancer, Imperial College London, London, UK.
  • Treede RD; Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Trials ; 23(1): 739, 2022 Sep 05.
Article em En | MEDLINE | ID: mdl-36064434
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dor / Medula Espinal / Analgésicos Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dor / Medula Espinal / Analgésicos Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article