Pattern formation of elliptic particles by two-body interactions: A model for dynamics of endothelial cells in angiogenesis.
J Theor Biol
; 555: 111300, 2022 12 21.
Article
em En
| MEDLINE
| ID: mdl-36209900
ABSTRACT
A two-dimensional mathematical model for dynamics of endothelial cells in angiogenesis is investigated. Angiogenesis is a morphogenic process in which new blood vessels emerge from an existing vascular network. Recently a one-dimensional discrete dynamical model has been proposed to reproduce elongation, bifurcation, and cell motility such as cell-mixing during angiogenesis on the assumption of a simple two-body interaction between endothelial cells. The present model is its two-dimensional extension, where endothelial cells are represented as the ellipses with the two-body interactions repulsive interaction due to excluded volume effect, attractive interaction through pseudopodia and rotation by contact. We show that the oblateness of ellipses and the magnitude of contact rotation significantly affect the shape of created vascular patterns and elongation of branches.
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Base de dados:
MEDLINE
Assunto principal:
Células Endoteliais
/
Neovascularização Patológica
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article