Kinetics and dynamics of quinidine-N-oxide in healthy subjects.
Clin Pharmacol Ther
; 42(3): 341-5, 1987 Sep.
Article
em En
| MEDLINE
| ID: mdl-3621790
ABSTRACT
The pharmacokinetics of a major metabolite of quinidine in humans, quinidine-N-oxide, were investigated after single oral doses (3 to 15 mg) in four healthy subjects. The concentration in serum and urine was determined by an HPLC assay. Because of a small volume of distribution, the elimination half-life of quinidine-N-oxide was only 2.5 +/- 0.28 hours (mean +/- SD), considerably shorter than that of quinidine. The renal clearance was 1.3 +/- 0.3 L/hr. Only 13.9% +/- 3.7% of the dose was recovered in urine as unchanged compound for up to 12 hours. Two unidentified compounds with the same retention time as quinidine and 3-hydroxyquinidine were found in the urine samples of two subjects. The free fraction in serum was 3.3% +/- 0.83%. No systematic changes in heart rate-corrected QT interval were observed up to concentrations of 500 ng/ml. The results indicate that quinidine-N-oxide, in contrast to 3-hydroxyquinidine, does not possess quinidine-like pharmacologic activity.
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Base de dados:
MEDLINE
Assunto principal:
Quinidina
/
Óxidos N-Cíclicos
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1987
Tipo de documento:
Article