Direct α-C-H Alkylation of Structurally Diverse Alcohols via Combined Tavaborole and Photoredox Catalysis.
Org Lett
; 24(41): 7637-7642, 2022 Oct 21.
Article
em En
| MEDLINE
| ID: mdl-36218287
ABSTRACT
Herein, we report a method that uses antifungal tavaborole as a co-catalyst for direct α-C-H alkylation of structurally diverse alcohols through photoredox catalysis. The protocol features mild conditions, remarkable scope, and wide functional group tolerance, which allows for the construction of a wide array of highly functionalized alcohols, including homoserine derivatives and C-glycosyl amino acids. We also demonstrate the synthetic applications of this methodology to the late-stage functionalization of pharmaceuticals and natural products.
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Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
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Álcoois
Idioma:
En
Ano de publicação:
2022
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Article