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Integrative analysis of a novel 5 methylated snoRNA genes prognostic signature in patients with glioma.
Yue, Xiaoyu; Zheng, Yinfei; Li, Lianxin; Yang, Zhihao; Chen, Zhigang; Wang, Yu; Wang, Zhiwei; Zhang, Deran; Bian, Erbao; Zhao, Bing.
Afiliação
  • Yue X; Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
  • Zheng Y; Cerebral Vascular Disease Research Center, Anhui Medical University, Hefei, 230601, China.
  • Li L; Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
  • Yang Z; Cerebral Vascular Disease Research Center, Anhui Medical University, Hefei, 230601, China.
  • Chen Z; Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
  • Wang Y; Cerebral Vascular Disease Research Center, Anhui Medical University, Hefei, 230601, China.
  • Wang Z; Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
  • Zhang D; Cerebral Vascular Disease Research Center, Anhui Medical University, Hefei, 230601, China.
  • Bian E; Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
  • Zhao B; Cerebral Vascular Disease Research Center, Anhui Medical University, Hefei, 230601, China.
Epigenomics ; 14(18): 1089-1104, 2022 09.
Article em En | MEDLINE | ID: mdl-36222052
ABSTRACT

Aim:

To explore the prognostic value of methylated snoRNA genes in glioma and construct a prognostic risk signature. Materials &

methods:

We retrieved clinical information and 450K methylation data from The Cancer Genome Atlas and obtained five methylated snoRNA genes. Then we established a risk signature and verified the effect of SNORA71B on glioma cells with functional assays.

Results:

A risk signature containing five methylated snoRNA genes was constructed and demonstrated to be an independent predictor of glioma prognosis. Silencing SNORA71B restrained the proliferation, migration and invasion of glioma cells and reduced the expression of mesenchymal and cell cycle marker proteins.

Conclusion:

This study constructed a methylated snoRNA gene risk signature, which may provide a reference for glioma patients' prognosis assessment.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioma Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioma Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article