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Pharmacological determination of the fractional block of Nav channels required to impair neuronal excitability and ex vivo seizures.
Thouta, Samrat; Waldbrook, Matthew G; Lin, Sophia; Mahadevan, Arjun; Mezeyova, Janette; Soriano, Maegan; Versi, Pareesa; Goodchild, Samuel J; Parrish, R Ryley.
Afiliação
  • Thouta S; Department of Cellular and Molecular Biology, Xenon Pharmaceuticals Inc., Burnaby, BC, Canada.
  • Waldbrook MG; Department of Cellular and Molecular Biology, Xenon Pharmaceuticals Inc., Burnaby, BC, Canada.
  • Lin S; Department of Cellular and Molecular Biology, Xenon Pharmaceuticals Inc., Burnaby, BC, Canada.
  • Mahadevan A; Department of Cellular and Molecular Biology, Xenon Pharmaceuticals Inc., Burnaby, BC, Canada.
  • Mezeyova J; Department of Cellular and Molecular Biology, Xenon Pharmaceuticals Inc., Burnaby, BC, Canada.
  • Soriano M; Department of Cellular and Molecular Biology, Xenon Pharmaceuticals Inc., Burnaby, BC, Canada.
  • Versi P; Department of Cellular and Molecular Biology, Xenon Pharmaceuticals Inc., Burnaby, BC, Canada.
  • Goodchild SJ; Department of Cellular and Molecular Biology, Xenon Pharmaceuticals Inc., Burnaby, BC, Canada.
  • Parrish RR; Department of Cellular and Molecular Biology, Xenon Pharmaceuticals Inc., Burnaby, BC, Canada.
Front Cell Neurosci ; 16: 964691, 2022.
Article em En | MEDLINE | ID: mdl-36246527
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Guideline Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Guideline Idioma: En Ano de publicação: 2022 Tipo de documento: Article