Aberrant Transferrin and Ferritin Upregulation Elicits Iron Accumulation and Oxidative Inflammaging Causing Ferroptosis and Undermines Estradiol Biosynthesis in Aging Rat Ovaries by Upregulating NF-&#922;b-Activated Inducible Nitric Oxide Synthase: First Demonstration of an Intricate Mechanism.

Sze, Stephen Cho Wing; Zhang, Liang; Zhang, Shiqing; Lin, Kaili; Ng, Tzi Bun; Ng, Man Ling; Lee, Kai-Fai; Lam, Jenny Ka Wing; Zhang, Zhang; Yung, Ken Kin Lam

Aberrant Transferrin and Ferritin Upregulation Elicits Iron Accumulation and Oxidative Inflammaging Causing Ferroptosis and Undermines Estradiol Biosynthesis in Aging Rat Ovaries by Upregulating NF-Κb-Activated Inducible Nitric Oxide Synthase: First Demonstration of an Intricate Mechanism.

Sze, Stephen Cho Wing; Zhang, Liang; Zhang, Shiqing; Lin, Kaili; Ng, Tzi Bun; Ng, Man Ling; Lee, Kai-Fai; Lam, Jenny Ka Wing; Zhang, Zhang; Yung, Ken Kin Lam.

Afiliação

Sze SCW; Department of Biology, Faculty of Science, Hong Kong Baptist University, Kowloon, Hong Kong SAR 999077, China.
Zhang L; Golden Meditech Center for NeuroRegeneration Sciences, Hong Kong Baptist University, Kowloon, Hong Kong SAR 999077, China.
Zhang S; School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR 999077, China.
Lin K; Department of Biology, Faculty of Science, Hong Kong Baptist University, Kowloon, Hong Kong SAR 999077, China.
Ng TB; Golden Meditech Center for NeuroRegeneration Sciences, Hong Kong Baptist University, Kowloon, Hong Kong SAR 999077, China.
Ng ML; JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, College of Pharmacy, Jinan University, Guangzhou 999077, China.
Lee KF; Department of Biology, Faculty of Science, Hong Kong Baptist University, Kowloon, Hong Kong SAR 999077, China.
Lam JKW; Golden Meditech Center for NeuroRegeneration Sciences, Hong Kong Baptist University, Kowloon, Hong Kong SAR 999077, China.
Zhang Z; School of Public Health, Guangzhou Medical University, Guangzhou 999077, China.
Yung KKL; School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR 999077, China.

Int J Mol Sci ; 23(20)2022 Oct 21.

Article em En | MEDLINE | ID: mdl-36293552

Assuntos

Ferroptose; NF-kappa B; Ratos; Animais; Feminino; NF-kappa B/metabolismo; Óxido Nítrico Sintase Tipo II/genética; Óxido Nítrico Sintase Tipo II/metabolismo; Fator 2 Relacionado a NF-E2/metabolismo; Fator de Necrose Tumoral alfa/metabolismo; Proteína 1 Associada a ECH Semelhante a Kelch/metabolismo; Ferritinas/metabolismo; Regulação para Cima; Nitritos/metabolismo; Transferrina/metabolismo; Estradiol/metabolismo; Nitratos/metabolismo; Ovário/metabolismo; Apoferritinas/metabolismo; Proteína 2 Reguladora do Ferro/metabolismo; Fosfolipídeo Hidroperóxido Glutationa Peroxidase; Envelhecimento; Estresse Oxidativo; Ferro/metabolismo; Receptores da Transferrina/metabolismo

Palavras-chave

NF-κB/iNOS; ferritin; ferroptosis; ovarian oxi-inflammaging; transferrin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: NF-kappa B / Ferroptose Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: NF-kappa B / Ferroptose Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article