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Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.
Tichenor, Mark S; Wiener, John J M; Rao, Navin L; Bacani, Genesis M; Wei, Jianmei; Pooley Deckhut, Charlotte; Barbay, J Kent; Kreutter, Kevin D; Chang, Leon; Clancy, Kathleen W; Murrey, Heather E; Wang, Weixue; Ahn, Kay; Huber, Michael; Rex, Elizabeth; Coe, Kevin J; Wu, Jiejun; Rui, Haopeng; Sepassi, Kia; Gaudiano, Marcello; Bekkers, Mariette; Cornelissen, Ivo; Packman, Kathryn; Seierstad, Mark; Xiouras, Christos; Bembenek, Scott D; Alexander, Richard; Milligan, Cynthia; Balasubramanian, Sriram; Lebsack, Alec D; Venable, Jennifer D; Philippar, Ulrike; Edwards, James P; Hirst, Gavin.
Afiliação
  • Tichenor MS; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Wiener JJM; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Rao NL; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.
  • Bacani GM; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Wei J; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Pooley Deckhut C; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Barbay JK; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.
  • Kreutter KD; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.
  • Chang L; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Clancy KW; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.
  • Murrey HE; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.
  • Wang W; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.
  • Ahn K; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.
  • Huber M; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Rex E; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Coe KJ; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Wu J; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Rui H; Janssen Research & Development, 4560 Jinke Road, Pudong New Area, Shanghai 201319, P. R. China.
  • Sepassi K; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Gaudiano M; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Bekkers M; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Cornelissen I; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Packman K; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Seierstad M; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Xiouras C; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Bembenek SD; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Alexander R; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.
  • Milligan C; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.
  • Balasubramanian S; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.
  • Lebsack AD; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Venable JD; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Philippar U; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Edwards JP; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
  • Hirst G; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States.
J Med Chem ; 65(21): 14326-14336, 2022 11 10.
Article em En | MEDLINE | ID: mdl-36314537
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Doenças Autoimunes / Lúpus Eritematoso Sistêmico Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Doenças Autoimunes / Lúpus Eritematoso Sistêmico Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article