Selective neurodegeneration generated by intravenous &#945;-synuclein pre-formed fibril administration is not associated with endogenous &#945;-synuclein levels in the rat brain.

Kuan, Wei-Li; Alfaidi, Maha; Horne, Catherine B; Vallin, Benjamin; Fox, Sarah; Fazal, Shaline V; Williams-Gray, Caroline H; Barker, Roger A

Selective neurodegeneration generated by intravenous α-synuclein pre-formed fibril administration is not associated with endogenous α-synuclein levels in the rat brain.

Kuan, Wei-Li; Alfaidi, Maha; Horne, Catherine B; Vallin, Benjamin; Fox, Sarah; Fazal, Shaline V; Williams-Gray, Caroline H; Barker, Roger A.

Afiliação

Kuan WL; John van Geest Centre for Brain Repair, Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK.
Alfaidi M; John van Geest Centre for Brain Repair, Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK.
Horne CB; John van Geest Centre for Brain Repair, Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK.
Vallin B; John van Geest Centre for Brain Repair, Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK.
Fox S; John van Geest Centre for Brain Repair, Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK.
Fazal SV; John van Geest Centre for Brain Repair, Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK.
Williams-Gray CH; John van Geest Centre for Brain Repair, Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK.
Barker RA; John van Geest Centre for Brain Repair, Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK.

Brain Pathol ; 33(3): e13128, 2023 05.

Article em En | MEDLINE | ID: mdl-36321260

Assuntos

Doença de Parkinson; alfa-Sinucleína; Ratos; Animais; alfa-Sinucleína/metabolismo; Doença de Parkinson/metabolismo; Encéfalo/patologia; Neurônios Dopaminérgicos/metabolismo; Administração Intravenosa

Palavras-chave

neurodegeneration; pre-formed fibrils; rabies virus glycoprotein (RVG); selective vulnerability; α-synuclein

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Alfa-Sinucleína Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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