Neutrophil-T cell crosstalk and the control of the host inflammatory response.
Immunol Rev
; 314(1): 36-49, 2023 03.
Article
em En
| MEDLINE
| ID: mdl-36326214
ABSTRACT
While fundamental in their innate role in combating infection and responding to injury, neutrophils are emerging as key modulators of adaptive immune responses. Such functions are attained via both soluble and nonsoluble effectors that enable at least two major downstream outcomes:
first, to mediate and control acute inflammatory responses and second, to regulate adaptive immunity and ultimately promoting the development and maintenance of immune tolerance either by releasing immuno-modulatory factors, including cytokines, or by directly interacting with cells of the adaptive immune system. Herein, we review these novel properties of neutrophils and redefine the pathophysiological functions of these fascinating multi-tasking cells, exploring the different mechanisms through which neutrophils are able to either enhance and orchestrate T cell pro-inflammatory responses or inhibit T cell activity to maintain immune tolerance.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Imunidade Inata
/
Neutrófilos
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article