Identification of Isonitrile-Containing Natural Products in Complex Biological Matrices through Ligation with Chlorooximes.

Schäfer, Rebecca J B; Wilson, Kayla; Biedermann, Maurice; Moore, Bradley S; Sieber, Simon; Wennemers, Helma

Schäfer, Rebecca J B; Wilson, Kayla; Biedermann, Maurice; Moore, Bradley S; Sieber, Simon; Wennemers, Helma.

Afiliação

Schäfer RJB; Laboratory of Organic Chemistry, ETH Zürich, Vladimir-Prelog-Weg 3, 8093, Zürich, Switzerland.
Wilson K; Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093, USA.
Biedermann M; Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093, USA.
Moore BS; Laboratory of Organic Chemistry, ETH Zürich, Vladimir-Prelog-Weg 3, 8093, Zürich, Switzerland.
Sieber S; Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093, USA.
Wennemers H; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA.

Chemistry ; 29(6): e202203277, 2023 Jan 27.

Article em En | MEDLINE | ID: mdl-36331430

Assuntos

Alcaloides; Produtos Biológicos; Poríferos; Animais; Produtos Biológicos/química

Palavras-chave

Chemoselective; chlorooximes; isonitriles; ligation; natural products; reactivity-based screening

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poríferos / Produtos Biológicos / Alcaloides Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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