From Differential DNA Methylation in COPD to Mitochondria: Regulation of AHRR Expression Affects Airway Epithelial Response to Cigarette Smoke.

Chen, Qing; Nwozor, Kingsley Okechukwu; van den Berge, Maarten; Slebos, Dirk-Jan; Faiz, Alen; Jonker, Marnix R; Boezen, H Marike; Heijink, Irene H; de Vries, Maaike

Chen, Qing; Nwozor, Kingsley Okechukwu; van den Berge, Maarten; Slebos, Dirk-Jan; Faiz, Alen; Jonker, Marnix R; Boezen, H Marike; Heijink, Irene H; de Vries, Maaike.

Afiliação

Chen Q; University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, 9713 GZ Groningen, The Netherlands.
Nwozor KO; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), 9713 GZ Groningen, The Netherlands.
van den Berge M; University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, 9713 GZ Groningen, The Netherlands.
Slebos DJ; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), 9713 GZ Groningen, The Netherlands.
Faiz A; Centre for Heart Lung Innovation, Department of Anesthesiology, Pharmacology & Therapeutics, The University of British Columbia, Vancouver, BC V6Z 1Y6, Canada.
Jonker MR; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), 9713 GZ Groningen, The Netherlands.
Boezen HM; University of Groningen, University Medical Center Groningen, Department of Pulmonology Disease, 9713 GZ Groningen, The Netherlands.
Heijink IH; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), 9713 GZ Groningen, The Netherlands.
de Vries M; University of Groningen, University Medical Center Groningen, Department of Pulmonology Disease, 9713 GZ Groningen, The Netherlands.

Cells ; 11(21)2022 10 29.

Article em En | MEDLINE | ID: mdl-36359818

Assuntos

Fumar Cigarros; Doença Pulmonar Obstrutiva Crônica; Receptores de Hidrocarboneto Arílico; Humanos; Fatores de Transcrição Hélice-Alça-Hélice Básicos/metabolismo; Fumar Cigarros/efeitos adversos; Metilação de DNA/genética; Mitocôndrias/metabolismo; Doença Pulmonar Obstrutiva Crônica/genética; Doença Pulmonar Obstrutiva Crônica/metabolismo; Receptores de Hidrocarboneto Arílico/genética; Receptores de Hidrocarboneto Arílico/metabolismo; Proteínas Repressoras/genética; Proteínas Repressoras/metabolismo; Nicotiana/efeitos adversos; Nicotiana/metabolismo

Palavras-chave

AHRR; COPD; CRISPR/Cas9; airway epithelial cells; cell death modalities; cigarette smoking; mitochondrial integrity; proliferation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Hidrocarboneto Arílico / Doença Pulmonar Obstrutiva Crônica / Fumar Cigarros Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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