NPInter v5.0: ncRNA interaction database in a new era.
Nucleic Acids Res
; 51(D1): D232-D239, 2023 01 06.
Article
em En
| MEDLINE
| ID: mdl-36373614
ABSTRACT
Noncoding RNAs (ncRNAs) play key regulatory roles in biological processes by interacting with other biomolecules. With the development of high-throughput sequencing and experimental technologies, extensive ncRNA interactions have been accumulated. Therefore, we updated the NPInter database to a fifth version to document these interactions. ncRNA interaction entries were doubled from 1 100 618 to 2 596 695 by manual literature mining and high-throughput data processing. We integrated global RNA-DNA interactions from iMARGI, ChAR-seq and GRID-seq, greatly expanding the number of RNA-DNA interactions (from 888 915 to 8 329 382). In addition, we collected different types of RNA interaction between SARS-CoV-2 virus and its host from recently published studies. Long noncoding RNA (lncRNA) expression specificity in different cell types from tumor single cell RNA-seq (scRNA-seq) data were also integrated to provide a cell-type level view of interactions. A new module named RBP was built to display the interactions of RNA-binding proteins with annotations of localization, binding domains and functions. In conclusion, NPInter v5.0 (http//bigdata.ibp.ac.cn/npinter5/) provides informative and valuable ncRNA interactions for biological researchers.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
RNA não Traduzido
/
Bases de Dados de Ácidos Nucleicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article