Adipose Tissue-Derived CCL5 Enhances Local Pro-Inflammatory Monocytic MDSCs Accumulation and Inflammation via CCR5 Receptor in High-Fat Diet-Fed Mice.

Chan, Pei-Chi; Lu, Chieh-Hua; Chien, Hung-Che; Tian, Yu-Feng; Hsieh, Po-Shiuan

Chan, Pei-Chi; Lu, Chieh-Hua; Chien, Hung-Che; Tian, Yu-Feng; Hsieh, Po-Shiuan.

Afiliação

Chan PC; Department of Physiology & Biophysics, National Defense Medical Center (NDMC), Taipei 114, Taiwan.
Lu CH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, NDMC, Taipei 114, Taiwan.
Chien HC; Department of Physiology & Biophysics, National Defense Medical Center (NDMC), Taipei 114, Taiwan.
Tian YF; Department of Surgery, Chi Mei Medical Center, Tainan 717, Taiwan.
Hsieh PS; Department of Physiology & Biophysics, National Defense Medical Center (NDMC), Taipei 114, Taiwan.

Int J Mol Sci ; 23(22)2022 Nov 17.

Article em En | MEDLINE | ID: mdl-36430701

Assuntos

Tecido Adiposo; Quimiocina CCL5; Inflamação; Células Supressoras Mieloides; Receptores CCR5; Animais; Camundongos; Tecido Adiposo/química; Tecido Adiposo/metabolismo; Dieta Hiperlipídica/efeitos adversos; Inflamação/metabolismo; Resistência à Insulina/genética; Camundongos Endogâmicos C57BL; Camundongos Knockout; Camundongos Obesos; Células Supressoras Mieloides/metabolismo; Obesidade/metabolismo; Receptores CCR5/genética; Receptores CCR5/metabolismo; Quimiocina CCL5/metabolismo; Quimiocina CCL5/farmacologia

Palavras-chave

CCL5; adipose tissue inflammation; diet-induced obesity; monocytic myeloid-derived suppressor cells (MDSCs)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tecido Adiposo / Quimiocina CCL5 / Receptores CCR5 / Células Supressoras Mieloides / Inflamação Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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