Neoplastic bone marrow invasion:rapid exclusion of hematological disease by flow cytometric routine panels.
Blood Cells Mol Dis
; 99: 102721, 2023 03.
Article
em En
| MEDLINE
| ID: mdl-36459839
ABSTRACT
Multiparametric flow cytometry is an extensively used technique to assess the presence of different cellular populations in immunology and hematology. During routine immunophenotyping analysis, it is not uncommon to face cells of non-hemopoietic origin, negative for CD45 and other myeloid, megakaryocytic, B and T lineage antigens and positive for at least one antibody among CD56, CD117 and CD138. If cytology cannot identify cell origin, especially in cases of unclear interpretation, the contribution of multiparametric flow cytometry analysis can be crucial. We report 6 patients with a clinical suspicion of hematological disease in which multiparametric flow cytometry was extremely useful to quickly exclude blood disorders in order to initiate patients to the most appropriate diagnostic process.
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Base de dados:
MEDLINE
Assunto principal:
Medula Óssea
/
Doenças Hematológicas
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article