A journey across dopamine Metabolism: A rotational study of DOPAC.
Spectrochim Acta A Mol Biomol Spectrosc
; 290: 122303, 2023 Apr 05.
Article
em En
| MEDLINE
| ID: mdl-36608514
ABSTRACT
DOPAC, a relevant scaffold in dopamine metabolism, was probed in the gas phase and interrogated by high-resolution rotational spectroscopy. Herein, three distinct conformers were isolated in a supersonic jet and identified for the first time through an examination of the trend of the rotational constants and the dipole moment selection rules. Additionally, we examined the plausible relaxation pathways of the low-energy conformers of DOPAC, which helped us to claim the indirect detection of two additional conformers, providing conclusive experimental evidence of the flexible nature of this biomolecule. The current investigation sheds some light on the differences between jet-cooled rotational experiments and matrix-isolation infrared spectroscopy.
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MEDLINE
Assunto principal:
Dopamina
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article