A Plasmodium falciparum RING Finger E3 Ubiquitin Ligase Modifies the Roles of PfMDR1 and PfCRT in Parasite Drug Responses.

Singh, Brajesh K; Zhang, Cui; Wu, Jian; Peng, Yu-Chih; He, Xiao; Tumas, Keyla C; Sá, Juliana M; Lane, Kristin D; Eastman, Richard T; Narum, David L; Wellems, Thomas E; Su, Xin-Zhuan

Singh, Brajesh K; Zhang, Cui; Wu, Jian; Peng, Yu-Chih; He, Xiao; Tumas, Keyla C; Sá, Juliana M; Lane, Kristin D; Eastman, Richard T; Narum, David L; Wellems, Thomas E; Su, Xin-Zhuan.

Afiliação

Singh BK; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.
Zhang C; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.
Wu J; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.
Peng YC; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.
He X; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.
Tumas KC; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.
Sá JM; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.
Lane KD; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.
Eastman RT; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.
Narum DL; Early Translation Branch, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, Rockville, Maryland, USA.
Wellems TE; Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Su XZ; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.

Antimicrob Agents Chemother ; 67(2): e0082122, 2023 02 16.

Article em En | MEDLINE | ID: mdl-36625569

Assuntos

Antimaláricos; Plasmodium falciparum; Proteínas de Protozoários; Ubiquitina-Proteína Ligases; Humanos; Antimaláricos/farmacologia; Cloroquina/farmacologia; Resistência a Medicamentos/genética; Malária Falciparum/tratamento farmacológico; Proteínas de Membrana Transportadoras/genética; Proteínas Associadas à Resistência a Múltiplos Medicamentos/genética; Plasmodium falciparum/efeitos dos fármacos; Plasmodium falciparum/genética; Proteínas de Protozoários/genética; Proteínas de Protozoários/metabolismo; Ubiquitina-Proteína Ligases/genética; Ubiquitina-Proteína Ligases/metabolismo

Palavras-chave

drug responses; gene knockdown; malaria; protein ubiquitination; rodent

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Proteínas de Protozoários / Ubiquitina-Proteína Ligases / Antimaláricos Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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