Microbiota-induced active translocation of peptidoglycan across the intestinal barrier dictates its within-host dissemination.
Proc Natl Acad Sci U S A
; 120(4): e2209936120, 2023 Jan 24.
Article
em En
| MEDLINE
| ID: mdl-36669110
ABSTRACT
Peptidoglycan, the major structural polymer forming the cell wall of bacteria, is an important mediator of physiological and behavioral effects in mammalian hosts. These effects are frequently linked to its translocation from the intestinal lumen to host tissues. However, the modality and regulation of this translocation across the gut barrier has not been precisely addressed. In this study, we characterized the absorption of peptidoglycan across the intestine and its systemic dissemination. We report that peptidoglycan has a distinct tropism for host organs when absorbed via the gut, most notably by favoring access to the brain. We demonstrate that intestinal translocation of peptidoglycan occurs through a microbiota-induced active process. This process is regulated by the parasympathetic pathway via the muscarinic acetylcholine receptors. Together, this study reveals fundamental parameters concerning the uptake of a major microbiota molecular signal from the steady-state gut.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptidoglicano
/
Microbiota
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article