Novel Prion Strain as Cause of Chronic Wasting Disease in a Moose, Finland.
Emerg Infect Dis
; 29(2): 323-332, 2023 02.
Article
em En
| MEDLINE
| ID: mdl-36692340
ABSTRACT
Our previous studies using gene-targeted mouse models of chronic wasting disease (CWD) demonstrated that Norway and North America cervids are infected with distinct prion strains that respond differently to naturally occurring amino acid variation at residue 226 of the prion protein. Here we performed transmissions in gene-targeted mice to investigate the properties of prions causing newly emergent CWD in moose in Finland. Although CWD prions from Finland and Norway moose had comparable responses to primary structural differences at residue 226, other distinctive criteria, including transmission kinetics, patterns of neuronal degeneration, and conformational features of prions generated in the brains of diseased mice, demonstrated that the strain properties of Finland moose CWD prions are different from those previously characterized in Norway CWD. Our findings add to a growing body of evidence for a diverse portfolio of emergent strains in Nordic countries that are etiologically distinct from the comparatively consistent strain profile of North America CWD.
Palavras-chave
CWD; Finland; Gt; Nordic; Norway; Tg; chronic wasting disease; gene-targeted; mice; moose; prions; transgenic
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Príons
/
Cervos
/
Doença de Emaciação Crônica
Tipo de estudo:
Prognostic_studies
Limite:
Animals
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article