Patchouli alcohol attenuates the cognitive deficits in a transgenic mouse model of Alzheimer's disease via modulating neuropathology and gut microbiota through suppressing C/EBPß/AEP pathway.

Xu, Qing-Qing; Su, Zi-Ren; Yang, Wen; Zhong, Mei; Xian, Yan-Fang; Lin, Zhi-Xiu

Xu, Qing-Qing; Su, Zi-Ren; Yang, Wen; Zhong, Mei; Xian, Yan-Fang; Lin, Zhi-Xiu.

Afiliação

Xu QQ; School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR, People's Republic of China.
Su ZR; Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Yang W; School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR, People's Republic of China.
Zhong M; School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR, People's Republic of China.
Xian YF; School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR, People's Republic of China. lisaxian@cuhk.edu.hk.
Lin ZX; School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR, People's Republic of China. linzx@cuhk.edu.hk.

J Neuroinflammation ; 20(1): 19, 2023 Jan 30.

Article em En | MEDLINE | ID: mdl-36717922

Assuntos

Doença de Alzheimer; Disfunção Cognitiva; Microbioma Gastrointestinal; Doenças Neurodegenerativas; Humanos; Camundongos; Animais; Doença de Alzheimer/terapia; Doença de Alzheimer/tratamento farmacológico; Camundongos Transgênicos; Proteínas tau/metabolismo; Doenças Neuroinflamatórias; Atividades Cotidianas; Disbiose; Disfunção Cognitiva/metabolismo; Precursor de Proteína beta-Amiloide/genética; Precursor de Proteína beta-Amiloide/metabolismo; Peptídeos beta-Amiloides/metabolismo; Cognição; Modelos Animais de Doenças

Palavras-chave

Alzheimer's disease; C/EBPß/AEP pathway; Gut microbiota; Neuropathology; Patchouli alcohol; TgCRND8

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas / Doença de Alzheimer / Disfunção Cognitiva / Microbioma Gastrointestinal Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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