[Research status and prospect of remyelination in multiple sclerosis based on "inflammation-tissue" homeostatic coupling].
Zhongguo Zhong Yao Za Zhi
; 48(1): 5-12, 2023 Jan.
Article
em Zh
| MEDLINE
| ID: mdl-36725252
ABSTRACT
Multiple sclerosis(MS) shows the pathological characteristics of "inflammatory injury of white matter" and "myelin repair disability" in the central nervous system(CNS). It is very essential for MS treatment and reduction of disease burden to strengthen repair, improve function, and reduce disability. Accordingly, different from the simple immunosuppression, we believe that key to strengthening remyelination and maintaining the "damage-repair" homeostasis of tissue is to change the current one-way immunosuppression strategy and achieve the "moderate pro-inflammation-effective inflammation removal" homeostasis. Traditional Chinese medicine shows huge potential in this strategy. Through literature research, this study summarized the research on remyelination, discussed the "mode-rate pro-inflammation-effective inflammation removal" homeostasis and the "damage-repair" homeostasis based on microglia, and summed up the key links in remyelination in MS. This review is expected to lay a theoretical basis for improving the function of MS patients and guide the application of traditional Chinese medicine.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Remielinização
/
Esclerose Múltipla
Limite:
Humans
Idioma:
Zh
Ano de publicação:
2023
Tipo de documento:
Article