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Vaccine hesitancy decreases in rheumatic diseases, long-term concerns remain in myositis: a comparative analysis of the COVAD surveys.
Sen, Parikshit; R, Naveen; Houshmand, Nazanin; Moghadam Kia, Siamak; Joshi, Mrudula; Saha, Sreoshy; Jagtap, Kshitij; Agarwal, Vishwesh; Nune, Arvind; Nikiphorou, Elena; Tan, Ai Lyn; Shinjo, Samuel Katsuyuki; Ziade, Nelly; Velikova, Tsvetelina; Milchert, Marcin; Parodis, Ioannis; Gracia-Ramos, Abraham Edgar; Cavagna, Lorenzo; Kuwana, Masataka; Knitza, Johannes; Makol, Ashima; Patel, Aarat; Pauling, John D; Wincup, Chris; Barman, Bhupen; Zamora Tehozol, Erick Adrian; Rojas Serrano, Jorge; García-De La Torre, Ignacio; Colunga-Pedraza, Iris J; Merayo-Chalico, Javier; Chibuzo, Okwara Celestine; Katchamart, Wanruchada; Akawatcharangura Goo, Phonpen; Shumnalieva, Russka; Chen, Yi-Ming; Hoff, Leonardo Santos; El Kibbi, Lina; Halabi, Hussein; Vaidya, Binit; Sazliyana Shaharir, Syahrul; Hasan, A T M Tanveer; Dey, Dzifa; Gutiérrez, Carlos Enrique Toro; Caballero-Uribe, Carlo Vinicio; Lilleker, James B; Salim, Babur; Gheita, Tamer; Chatterjee, Tulika; Distler, Oliver; Saavedra, Miguel A.
Afiliação
  • Sen P; Maulana Azad Medical College, New Delhi, Delhi, India.
  • R N; Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
  • Houshmand N; Department of Internal Medicine, Kirk Kerkorian School of Medicine, University of Nevada Las Vegas, Las Vegas, NV, USA.
  • Moghadam Kia S; Myositis Center and Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Joshi M; Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals, Pune, India.
  • Saha S; Mymensingh Medical College, Mymensingh, Bangladesh.
  • Jagtap K; Seth Gordhandhas Sunderdas Medical College and King Edwards Memorial Hospital, Mumbai, Maharashtra, India.
  • Agarwal V; Mahatma Gandhi Mission Medical College, Navi Mumbai, Maharashtra, India.
  • Nune A; Southport and Ormskirk Hospital NHS Trust, Southport, UK.
  • Nikiphorou E; Centre for Rheumatic Diseases, King's College London, London, UK.
  • Tan AL; Rheumatology Department, King's College Hospital, London, UK.
  • Shinjo SK; NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK.
  • Ziade N; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
  • Velikova T; Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
  • Milchert M; Rheumatology Department, Saint-Joseph University, Beirut, Lebanon.
  • Parodis I; Rheumatology Department, Hotel-Dieu de France Hospital, Beirut, Lebanon.
  • Gracia-Ramos AE; Medical Faculty, Sofia University St. Kliment Ohridski, Sofia, Bulgaria.
  • Cavagna L; Department of Internal Medicine, Rheumatology, Diabetology, Geriatrics and Clinical Immunology, Pomeranian Medical University, Szczecin, Poland.
  • Kuwana M; Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
  • Knitza J; Department of Rheumatology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
  • Makol A; Department of Internal Medicine, General Hospital, National Medical Center "La Raza", Instituto Mexicano del Seguro Social, Mexico City, Mexico.
  • Patel A; Rheumatology Unit, Dipartimento di Medicine Interna e Terapia Medica, Università degli studi di Pavia, Pavia, Lombardy, Italy.
  • Pauling JD; Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan.
  • Wincup C; Medizinische Klinik 3-Rheumatologie und Immunologie, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Deutschland.
  • Barman B; Division of Rheumatology, Mayo Clinic, Rochester, MN, USA.
  • Zamora Tehozol EA; Bon Secours Rheumatology Center and Division of Pediatric Rheumatology, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Rojas Serrano J; Bristol Medical School Translational Health Sciences, University of Bristol, UK.
  • García-De La Torre I; Department of Rheumatology, North Bristol NHS Trust, Bristol, UK.
  • Colunga-Pedraza IJ; Department of Rheumatology, Division of Medicine, Rayne Institute, University College London, UK.
  • Merayo-Chalico J; Centre for Adolescent Rheumatology Versus Arthritis at UCL, UCLH, GOSH, London, UK.
  • Chibuzo OC; Department of General Medicine, All India Institute of Medical Sciences (AIIMS), Guwahati, India.
  • Katchamart W; Rheumatology, Medical Care & Research, Centro Medico Pensiones Hospital, Instituto Mexicano del Seguro Social Delegación Yucatán, Yucatán, Mexcio.
  • Akawatcharangura Goo P; Rheumatologist and Clinical Investigator, Interstitial Lung Disease and Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico.
  • Shumnalieva R; Departamento de Inmunología y Reumatología, Hospital General de Occidente and Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
  • Chen YM; Rheumatology, Hospital Universitario Dr Jose Eleuterio Gonzalez, Monterrey, Mexico.
  • Hoff LS; Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
  • El Kibbi L; Department of Medicine, University of Nigeria Teaching Hospital, Ituku-Ozalla/University of Nigeria, Enugu, Nigeria.
  • Halabi H; Division of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
  • Vaidya B; Department of Medicine, Queen Savang Vadhana Memorial Hospital, Chonburi, Thailand.
  • Sazliyana Shaharir S; Department of Rheumatology, Clinic of Rheumatology, University Hospital 'St. Ivan Rilski', Medical University-Sofia, Bulgaria.
  • Hasan ATMT; Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung City, Taiwan.
  • Dey D; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
  • Gutiérrez CET; School of Medicine, Universidade Potiguar (UnP), Natal, Brazil.
  • Caballero-Uribe CV; Rheumatology Unit, Internal Medicine Department, Specialized Medical Center, Riyadh, Saudi Arabia.
  • Lilleker JB; Department of Internal Medicine, Section of Rheumatology, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.
  • Salim B; National Center for Rheumatic Diseases (NCRD), Kathmandu, Nepal.
  • Gheita T; Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia.
  • Chatterjee T; Department of Rheumatology, Enam Medical College & Hospital, Dhaka, Bangladesh.
  • Distler O; Rheumatology Unit, Department of Medicine and Therapeutics, University of Ghana Medical School, College of Health Sciences, Accra, Ghana.
  • Saavedra MA; Reference Center for Osteoporosis, Rheumatology and Dermatology, Pontifica Universidad Javeriana Cali, Colombia.
Rheumatology (Oxford) ; 62(10): 3291-3301, 2023 10 03.
Article em En | MEDLINE | ID: mdl-36734536
OBJECTIVE: COVID-19 vaccines have a favorable safety profile in patients with autoimmune rheumatic diseases (AIRDs) such as idiopathic inflammatory myopathies (IIMs); however, hesitancy continues to persist among these patients. Therefore, we studied the prevalence, predictors and reasons for hesitancy in patients with IIMs, other AIRDs, non-rheumatic autoimmune diseases (nrAIDs) and healthy controls (HCs), using data from the two international COVID-19 Vaccination in Autoimmune Diseases (COVAD) e-surveys. METHODS: The first and second COVAD patient self-reported e-surveys were circulated from March to December 2021, and February to June 2022 (ongoing). We collected data on demographics, comorbidities, COVID-19 infection and vaccination history, reasons for hesitancy, and patient reported outcomes. Predictors of hesitancy were analysed using regression models in different groups. RESULTS: We analysed data from 18 882 (COVAD-1) and 7666 (COVAD-2) respondents. Reassuringly, hesitancy decreased from 2021 (16.5%) to 2022 (5.1%) (OR: 0.26; 95% CI: 0.24, 0.30, P < 0.001). However, concerns/fear over long-term safety had increased (OR: 3.6; 95% CI: 2.9, 4.6, P < 0.01). We noted with concern greater skepticism over vaccine science among patients with IIMs than AIRDs (OR: 1.8; 95% CI: 1.08, 3.2, P = 0.023) and HCs (OR: 4; 95% CI: 1.9, 8.1, P < 0.001), as well as more long-term safety concerns/fear (IIMs vs AIRDs - OR: 1.9; 95% CI: 1.2, 2.9, P = 0.001; IIMs vs HCs - OR: 5.4 95% CI: 3, 9.6, P < 0.001). Caucasians [OR 4.2 (1.7-10.3)] were likely to be more hesitant, while those with better PROMIS physical health score were less hesitant [OR 0.9 (0.8-0.97)]. CONCLUSION: Vaccine hesitancy has decreased from 2021 to 2022, long-term safety concerns remain among patients with IIMs, particularly in Caucasians and those with poor physical function.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Doenças Reumáticas / COVID-19 / Miosite Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Doenças Reumáticas / COVID-19 / Miosite Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article