What repeat expansion disorders can teach us about the Central Dogma.
Mol Cell
; 83(3): 324-329, 2023 02 02.
Article
em En
| MEDLINE
| ID: mdl-36736306
ABSTRACT
Pathogenic repeat sequences underlie several human disorders, including amyotrophic lateral sclerosis, Huntington's disease, and myotonic dystrophy. Here, we speak to several researchers about how repeat sequences have been implicated in affecting all aspects of the Central Dogma of molecular biology through their effects on DNA, RNA, and protein.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença de Huntington
/
Esclerose Lateral Amiotrófica
/
Distrofia Miotônica
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article