The relationship between hippocampal amyloid beta burden and spatial distribution of neurofibrillary degeneration.
Alzheimers Dement
; 19(7): 3158-3170, 2023 07.
Article
em En
| MEDLINE
| ID: mdl-36738450
ABSTRACT
INTRODUCTION:
Neurofibrillary degeneration in Alzheimer's disease (AD) typically involves the entorhinal cortex and CA1 subregion of the hippocampus early in the disease process, whereas in primary age-related tauopathy (PART), there is an early selective vulnerability of the CA2 subregion.METHODS:
Image analysis-based quantitative pixel assessments were used to objectively evaluate amyloid beta (Aß) burden in the medial temporal lobe in relation to the distribution of hyperphosphorylated-tau (p-tau) in 142 cases of PART and AD.RESULTS:
Entorhinal, CA1, CA3, and CA4 p-tau deposition levels are significantly correlated with Aß burden, while CA2 p-tau is not. Furthermore, the CA2/CA1 p-tau ratio is inversely correlated with Aß burden and distribution. In addition, cognitive impairment is correlated with overall p-tau burden.DISCUSSION:
These data indicate that the presence and extent of medial temporal lobe Aß may determine the distribution and spread of neurofibrillary degeneration. The resulting p-tau distribution patterns may discriminate between PART and AD. HIGHLIGHTS Subregional hyperphosphorylated-tau (p-tau) distribution is influenced by hippocampal amyloid beta burden. Higher CA2/CA1 p-tau ratio is predictive of primary age-related tauopathy-like neuropathology. Cognitive function is correlated with the overall hippocampal p-tau burden.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tauopatias
/
Doença de Alzheimer
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article