Anti-Inflammatory Activities of Monoterpene and Sesquiterpene Glycosides from the Aqueous Extract of Artemisia annua L.
Chem Biodivers
; 20(3): e202201237, 2023 Mar.
Article
em En
| MEDLINE
| ID: mdl-36740572
ABSTRACT
Artemisia annua L. is a Chinese medicinal herb, but the origin of its pharmacological properties, including its anti-inflammatory activity, remain unknown. In this study, five new monoterpene glycosides (1-5) and two new sesquiterpene glycosides (6 and 7) were isolated from the aqueous extract of the aerial parts of A.â
annua. The structures of these glycosides were determined using high-resolution electrospray ionization mass spectrometry, nuclear magnetic resonance spectroscopy, electronic circular dichroism calculations, and chemical hydrolysis methods. The anti-inflammatory activities of the isolated compounds were evaluated by down-regulating interleukin-6 (IL-6) in lipopolysaccharide-stimulated RAW 264.7 macrophages. Notably, all the new compounds significantly inhibited the expression of IL-6 in a dose-dependent manner.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
/
Artemisia
/
Artemisia annua
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article