Young and undamaged recombinant albumin alleviates T2DM by improving hepatic glycolysis through EGFR and protecting islet ß cells in mice.

Liu, Hongyi; Ju, Anji; Dong, Xuan; Luo, Zongrui; Tang, Jiaze; Ma, Boyuan; Fu, Yan; Luo, Yongzhang

Liu, Hongyi; Ju, Anji; Dong, Xuan; Luo, Zongrui; Tang, Jiaze; Ma, Boyuan; Fu, Yan; Luo, Yongzhang.

Afiliação

Liu H; School of Life Sciences, Tsinghua University, Beijing, 100084, China.
Ju A; Tsinghua-Peking Joint Center for Life Sciences, Beijing, 100084, China.
Dong X; The National Engineering Research Center for Protein Technology, Beijing, 100084, China.
Luo Z; Beijing Key Laboratory for Protein Therapeutics, Beijing, 100084, China.
Tang J; School of Life Sciences, Tsinghua University, Beijing, 100084, China.
Ma B; The National Engineering Research Center for Protein Technology, Beijing, 100084, China.
Fu Y; Beijing Key Laboratory for Protein Therapeutics, Beijing, 100084, China.
Luo Y; School of Life Sciences, Tsinghua University, Beijing, 100084, China.

J Transl Med ; 21(1): 89, 2023 02 06.

Article em En | MEDLINE | ID: mdl-36747238

Assuntos

Diabetes Mellitus Tipo 2; Resistência à Insulina; Camundongos; Animais; Glicemia/metabolismo; Insulina; Fosfatidilinositol 3-Quinases/metabolismo; Glucose/metabolismo; Camundongos Obesos; Glicólise; Albumina Sérica/metabolismo; Receptores ErbB/metabolismo; Resistência à Insulina/fisiologia

Palavras-chave

Glycolysis; Lipotoxicity; Type 2 diabetes mellitus; rMSA; ß-Cell apoptosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Diabetes Mellitus Tipo 2 Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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