Investigation of simplified physiologically-based pharmacokinetic models in rat and human.

Yau, Estelle; Olivares-Morales, Andrés; Ogungbenro, Kayode; Aarons, Leon; Gertz, Michael

Yau, Estelle; Olivares-Morales, Andrés; Ogungbenro, Kayode; Aarons, Leon; Gertz, Michael.

Afiliação

Yau E; Centre for Applied Pharmacokinetic Research (CAPKR), The University of Manchester, Manchester, UK.
Olivares-Morales A; Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, Basel, Switzerland.
Ogungbenro K; Sanofi R&D, DMPK France, Paris, France.
Aarons L; Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, Basel, Switzerland.
Gertz M; Centre for Applied Pharmacokinetic Research (CAPKR), The University of Manchester, Manchester, UK.

CPT Pharmacometrics Syst Pharmacol ; 12(3): 333-345, 2023 03.

Article em En | MEDLINE | ID: mdl-36754967

Assuntos

Fígado; Modelos Biológicos; Ratos; Humanos; Animais; Distribuição Tecidual; Fígado/metabolismo; Rim; Diazepam

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fígado / Modelos Biológicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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