Improving detection of fMRI activation at 1.5 T using high permittivity ceramics.

In this work, we propose an application of high permittivity materials (HPMs) to improve functional magnetic resonance imaging (fMRI) at 1.5 T, increasing the receive (Rx) sensitivity of a commercial multi-channel head coil. To evaluate the transmit efficiency, specific absorption rate (SAR), and the signal-to-noise ratio (SNR) changes introduced by the HPMs with relative permittivity of 4500, we considered the following configurations in simulation: a whole-body birdcage coil and an Rx-only multi-channel head coil with and without the HPM blocks in the presence of a homogeneous head phantom or a human body model. Experimental studies were also performed with a phantom and with volunteers. Seven healthy volunteers enrolled in a prospective study of fMRI activation in the motor cortex with and without HPMs. fMRI data were analyzed using group-level paired T-tests between acquisitions with and without HPM blocks. Both electromagnetic simulations and experimental measurements showed ∼25% improvement in the Rx sensitivity of a commercial head coil in the areas of interest when HPM blocks were placed in close proximity. It increased the detected motor cortex fMRI activation volume by an average of 56%, thus resulting in more sensitive functional imaging at 1.5 T.