Extensive blood transcriptome analysis reveals cellular signaling networks activated by circulating glycocalyx components reflecting vascular injury in COVID-19.

Borrmann, Melanie; Brandes, Florian; Kirchner, Benedikt; Klein, Matthias; Billaud, Jean-Noël; Reithmair, Marlene; Rehm, Markus; Schelling, Gustav; Pfaffl, Michael W; Meidert, Agnes S

Borrmann, Melanie; Brandes, Florian; Kirchner, Benedikt; Klein, Matthias; Billaud, Jean-Noël; Reithmair, Marlene; Rehm, Markus; Schelling, Gustav; Pfaffl, Michael W; Meidert, Agnes S.

Afiliação

Borrmann M; Department of Anesthesiology, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.
Brandes F; Department of Anesthesiology, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.
Kirchner B; Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.
Klein M; Department of Neurology, University Hospital, Ludwig-Maximilians-University of Munich, Munich, Germany.
Billaud JN; QIAGEN Digital Insights, Redwood City, United States.
Reithmair M; Institute of Human Genetics, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.
Rehm M; Department of Anesthesiology, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.
Schelling G; Department of Anesthesiology and intensive Care Medicine, Hospital Agatharied, Hausham, Germany.
Pfaffl MW; Department of Anesthesiology, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.
Meidert AS; Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.

Front Immunol ; 14: 1129766, 2023.

Article em En | MEDLINE | ID: mdl-36776845

Assuntos

COVID-19; Síndrome do Desconforto Respiratório; Lesões do Sistema Vascular; Humanos; Glicocálix/metabolismo; Células Endoteliais; Sindecana-1/metabolismo; Lesões do Sistema Vascular/metabolismo; Ácido Hialurônico/metabolismo; COVID-19/metabolismo; SARS-CoV-2; Síndrome do Desconforto Respiratório/tratamento farmacológico; Perfilação da Expressão Gênica

Palavras-chave

COVID-19; acute respiratory distress syndrome; cell-free microRNAs; endothelial dysfunction; extracellular vesicles; glycocalyx; small RNA

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome do Desconforto Respiratório / Lesões do Sistema Vascular / COVID-19 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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