Investigation of the pharmacokinetics and metabolic fate of Fasiglifam (TAK-875) in male and female rats following oral and intravenous administration.

Molloy, Billy J; King, Adam; Gethings, Lee A; Plumb, Robert S; Mortishire-Smith, Russell J; Wilson, Ian D

Molloy, Billy J; King, Adam; Gethings, Lee A; Plumb, Robert S; Mortishire-Smith, Russell J; Wilson, Ian D.

Afiliação

Molloy BJ; Waters Corporation, Wilmslow, UK.
King A; Waters Corporation, Wilmslow, UK.
Gethings LA; Waters Corporation, Wilmslow, UK.
Plumb RS; Waters Corporation, Milford, MA, USA.
Mortishire-Smith RJ; Waters Corporation, Wilmslow, UK.
Wilson ID; Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College, London, UK.

Xenobiotica ; 53(2): 93-105, 2023 Feb.

Article em En | MEDLINE | ID: mdl-36794569

Assuntos

Receptores Acoplados a Proteínas G; Sulfonas; Ratos; Masculino; Feminino; Animais; Ratos Sprague-Dawley; Administração Intravenosa; Receptores Acoplados a Proteínas G/agonistas; Administração Oral; Injeções Intravenosas

Palavras-chave

Fasiglifam; metabolite profiling; novel metabolites; oxidative decarboxylaton; pharmacokinetics; sex differences

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfonas / Receptores Acoplados a Proteínas G Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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