Your browser doesn't support javascript.
loading
Addition of the FTD Module to the Neuropsychiatric Inventory improves classification of frontotemporal dementia spectrum disorders.
Jiskoot, Lize C; Russell, Lucy L; Greaves, Caroline V; van Schaik, Esther; van den Berg, Esther; Poos, Jackie M; de Boer, Liset; Donker Kaat, Laura; Seelaar, Harro; Pijnenburg, Yolande A L; van Swieten, John C; Rohrer, Jonathan D.
Afiliação
  • Jiskoot LC; Department of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Room NF-331, Dr. Molenwaterplein 40, 3015 CE, Rotterdam, The Netherlands. l.c.jiskoot@erasmusmc.nl.
  • Russell LL; Dementia Research Centre, Department of Neurodegenerative Disease, University College London Queen Square Institute of Neurology, London, UK. l.c.jiskoot@erasmusmc.nl.
  • Greaves CV; Dementia Research Centre (DRC), National Hospital for Neurology and Neurosurgery, University College London (UCL), 8-11 Queen Square, Box 16, London, WC1N 3BG, UK. l.c.jiskoot@erasmusmc.nl.
  • van Schaik E; Dementia Research Centre, Department of Neurodegenerative Disease, University College London Queen Square Institute of Neurology, London, UK.
  • van den Berg E; Dementia Research Centre, Department of Neurodegenerative Disease, University College London Queen Square Institute of Neurology, London, UK.
  • Poos JM; Department of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Room NF-331, Dr. Molenwaterplein 40, 3015 CE, Rotterdam, The Netherlands.
  • de Boer L; Department of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Room NF-331, Dr. Molenwaterplein 40, 3015 CE, Rotterdam, The Netherlands.
  • Donker Kaat L; Department of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Room NF-331, Dr. Molenwaterplein 40, 3015 CE, Rotterdam, The Netherlands.
  • Seelaar H; Department of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Room NF-331, Dr. Molenwaterplein 40, 3015 CE, Rotterdam, The Netherlands.
  • Pijnenburg YAL; Department of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Room NF-331, Dr. Molenwaterplein 40, 3015 CE, Rotterdam, The Netherlands.
  • van Swieten JC; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Rohrer JD; Department of Neurology and Alzheimer Center Erasmus MC, Erasmus MC University Medical Center, Room NF-331, Dr. Molenwaterplein 40, 3015 CE, Rotterdam, The Netherlands.
J Neurol ; 270(5): 2674-2687, 2023 May.
Article em En | MEDLINE | ID: mdl-36811680
ABSTRACT
Most neuropsychiatric symptoms (NPS) common in frontotemporal dementia (FTD) are currently not part of the Neuropsychiatric Inventory (NPI). We piloted an FTD Module that included eight extra items to be used in conjunction with the NPI. Caregivers of patients with behavioural variant FTD (n = 49), primary progressive aphasia (PPA; n = 52), Alzheimer's dementia (AD; n = 41), psychiatric disorders (n = 18), presymptomatic mutation carriers (n = 58) and controls (n = 58) completed the NPI and FTD Module. We investigated (concurrent and construct) validity, factor structure and internal consistency of the NPI and FTD Module. We performed group comparisons on item prevalence, mean item and total NPI and NPI with FTD Module scores, and multinomial logistic regression to determine its classification abilities. We extracted four components, together explaining 64.1% of the total variance, of which the largest indicated the underlying dimension 'frontal-behavioural symptoms'. Whilst apathy (original NPI) occurred most frequently in AD, logopenic and non-fluent variant PPA, the most common NPS in behavioural variant FTD and semantic variant PPA were loss of sympathy/empathy and poor response to social/emotional cues (part of FTD Module). Patients with primary psychiatric disorders and behavioural variant FTD showed the most severe behavioural problems on both the NPI as well as the NPI with FTD Module. The NPI with FTD Module correctly classified more FTD patients than the NPI alone. By quantifying common NPS in FTD the NPI with FTD Module has large diagnostic potential. Future studies should investigate whether it can also prove a useful addition to the NPI in therapeutic trials.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Demência Frontotemporal / Doença de Alzheimer Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Demência Frontotemporal / Doença de Alzheimer Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article