The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR <sup>+</sup> CD8 <sup>+</sup> effector state and its deletion improves checkpoint blockade.

McClory, Susan E; Bardhan, Oishi; Rome, Kelly S; Giles, Josephine R; Baxter, Amy E; Xu, Lanwei; Gimotty, Phyllis A; Faryabi, Robert B; Wherry, E John; Pear, Warren S; Jordan, Martha S

The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR ⁺ CD8 ⁺ effector state and its deletion improves checkpoint blockade.

McClory, Susan E; Bardhan, Oishi; Rome, Kelly S; Giles, Josephine R; Baxter, Amy E; Xu, Lanwei; Gimotty, Phyllis A; Faryabi, Robert B; Wherry, E John; Pear, Warren S; Jordan, Martha S.

Afiliação

McClory SE; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Bardhan O; Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Rome KS; Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Giles JR; Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Baxter AE; Department of Pathology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Xu L; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
Gimotty PA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Faryabi RB; Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Wherry EJ; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
Pear WS; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jordan MS; Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

bioRxiv ; 2023 Feb 16.

Article em En | MEDLINE | ID: mdl-36824931

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article