Human Cytochrome P450 1, 2, 3 Families as Pharmacogenes with Emphases on Their Antimalarial and Antituberculosis Drugs and Prevalent African Alleles.

Chamboko, Chiratidzo R; Veldman, Wayde; Tata, Rolland Bantar; Schoeberl, Birgit; Tastan Bishop, Özlem

Chamboko, Chiratidzo R; Veldman, Wayde; Tata, Rolland Bantar; Schoeberl, Birgit; Tastan Bishop, Özlem.

Afiliação

Chamboko CR; Research Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Makhanda 6139, South Africa.
Veldman W; Research Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Makhanda 6139, South Africa.
Tata RB; Research Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Makhanda 6139, South Africa.
Schoeberl B; Translational Medicine, Novartis Institutes for BioMedical Research, 220 Massachusetts Ave, Cambridge, MA 02139, USA.
Tastan Bishop Ö; Research Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Makhanda 6139, South Africa.

Int J Mol Sci ; 24(4)2023 Feb 08.

Article em En | MEDLINE | ID: mdl-36834793

Assuntos

Antimaláricos; Humanos; Citocromo P-450 CYP2D6/genética; Citocromo P-450 CYP2C8/genética; Citocromo P-450 CYP2C19/genética; Citocromo P-450 CYP3A/genética; Alelos; Citocromo P-450 CYP2B6/genética; Antituberculosos; Citocromo P-450 CYP2C9/genética; Sistema Enzimático do Citocromo P-450/metabolismo

Palavras-chave

CYP metabolism; SNPs; missense mutations; personalized medicine; polymorphisms

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antimaláricos Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antimaláricos Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article