Sirolimus suppresses circulating fibrocytes in idiopathic pulmonary fibrosis in a randomized controlled crossover trial.

Gomez-Manjarres, Diana C; Axell-House, Dierdre B; Patel, Divya C; Odackal, John; Yu, Victor; Burdick, Marie D; Mehrad, Borna

Gomez-Manjarres, Diana C; Axell-House, Dierdre B; Patel, Divya C; Odackal, John; Yu, Victor; Burdick, Marie D; Mehrad, Borna.

Afiliação

Gomez-Manjarres DC; Division of Pulmonary, Critical Care, and Sleep Medicine, University of Florida, Gainesville, Florida, USA.
Axell-House DB; Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Patel DC; Division of Pulmonary, Critical Care, and Sleep Medicine, University of Florida, Gainesville, Florida, USA.
Odackal J; Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Yu V; Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Burdick MD; Division of Pulmonary, Critical Care, and Sleep Medicine, University of Florida, Gainesville, Florida, USA.
Mehrad B; Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA.

JCI Insight ; 8(8)2023 04 24.

Article em En | MEDLINE | ID: mdl-36853800

Assuntos

Fibrose Pulmonar Idiopática; Sirolimo; Estados Unidos; Animais; Sirolimo/efeitos adversos; Estudos Cross-Over; Fibrose Pulmonar Idiopática/tratamento farmacológico; Fibrose Pulmonar Idiopática/metabolismo; Pulmão/metabolismo; Fibroblastos/metabolismo

Palavras-chave

Chemokines; Drug therapy; Fibrosis; Pulmonology

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sirolimo / Fibrose Pulmonar Idiopática Tipo de estudo: Clinical_trials Limite: Animals País/Região como assunto: America do norte Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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