Canagliflozin ameliorates epithelial-mesenchymal transition in high-salt diet-induced hypertensive renal injury through restoration of sirtuin 3 expression and the reduction of oxidative stress.

Wang, Zhongli; Zhai, Jianlong; Zhang, Tingting; He, Lili; Ma, Sai; Zuo, Qingjuan; Zhang, Guorui; Wang, Yan; Guo, Yifang

Wang, Zhongli; Zhai, Jianlong; Zhang, Tingting; He, Lili; Ma, Sai; Zuo, Qingjuan; Zhang, Guorui; Wang, Yan; Guo, Yifang.

Afiliação

Wang Z; Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, China; Department of Physical Examination Center, Hebei General Hospital, Shijiazhuang, Hebei, China.
Zhai J; Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, China; Department of Cardiology, Hebei General Hospital, Shijiazhuang, Hebei, China.
Zhang T; Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, China; Department of Geriatric Cardiology, Hebei General Hospital, Shijiazhuang, Hebei, China.
He L; Department of Geriatric Cardiology, Hebei General Hospital, Shijiazhuang, Hebei, China.
Ma S; Department of Internal Medicine, Hebei General Hospital, Shijiazhuang, Hebei, China.
Zuo Q; Department of Geriatric Cardiology, Hebei General Hospital, Shijiazhuang, Hebei, China.
Zhang G; Department of Cardiology, The Third Hospital of Shijiazhuang City Affiliated to Hebei Medical University, Shijiazhuang, Hebei, China.
Wang Y; Department of Geriatric Cardiology, Hebei General Hospital, Shijiazhuang, Hebei, China.
Guo Y; Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, China; Department of Geriatric Cardiology, Hebei General Hospital, Shijiazhuang, Hebei, China. Electronic address: yifangguo@hebmu.edu.cn.

Biochem Biophys Res Commun ; 653: 53-61, 2023 04 23.

Article em En | MEDLINE | ID: mdl-36857900

Assuntos

Hipertensão; Nefropatias; Sirtuína 3; Animais; Humanos; Ratos; Canagliflozina/farmacologia; Canagliflozina/uso terapêutico; Catalase/metabolismo; Dieta; Transição Epitelial-Mesenquimal; Fibrose; Hipertensão/metabolismo; Irbesartana/metabolismo; Irbesartana/farmacologia; Rim/patologia; Nefropatias/patologia; Estresse Oxidativo; Ratos Endogâmicos Dahl; Sirtuína 3/genética; Sirtuína 3/metabolismo; Cloreto de Sódio na Dieta/efeitos adversos; Cloreto de Sódio na Dieta/metabolismo

Palavras-chave

Canagliflozin; Epithelial-mesenchymal transition; High-salt diet; Hypertension; Kidney; SGLT2 inhibitors

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sirtuína 3 / Hipertensão / Nefropatias Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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