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Extranodal natural killer/T-cell lymphoma nasal type in a western population: Molecular profiling identifies new therapeutic targets.
Gonzalez Barca, Eva; Tomás-Roca, Laura; Esteve, Anna; Rodriguez, Marta; Gato, Lucía; Alonso-Alonso, Ruth; Martin Garcia-Sancho, Alejandro; Cordoba, Raul; Monter-Rovira, Anna; Bastos-Oreiro, Mariana; Bergua Burgues, Juan Miguel; Sayas, Maria Jose; Viguria Alegria, Maria Cruz; Sanchez-Blanco, Jose Javier; Roig Pellicer, Monica; Luzardo Henriquez, Hugo Daniel; de Oña, Raquel; Cabezudo, Maria Elena; Infante, Maria Stefania; Queizán Hernández, José Antonio; Sanz-Pamplona, Rebeca; Blanco, Oscar; Mozos, Ana; Climent, Fina; Piris, Miguel Angel.
Afiliação
  • Gonzalez Barca E; Hematology Department, Institut Català d'Oncologia Hospitalet, Hospital Duran i Reynals, IDIBELL, Universitat de Barcelona, Barcelona, Spain.
  • Tomás-Roca L; Pathology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain.
  • Esteve A; Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program (ODAP), Medical Oncology Department, B-ARGO Badalona, Catalan Institute of Oncology, Barcelona, Spain.
  • Rodriguez M; Pathology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain.
  • Gato L; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), ISCIII, Madrid, Spain.
  • Alonso-Alonso R; Pathology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain.
  • Martin Garcia-Sancho A; Pathology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain.
  • Cordoba R; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), ISCIII, Madrid, Spain.
  • Monter-Rovira A; Hematology Department, Hospital Clínico Universitario de Salamanca (CAUSA/IBSAL), Salamanca, Spain.
  • Bastos-Oreiro M; Hematology Department, Fundación Jiménez Díaz, Madrid, Spain.
  • Bergua Burgues JM; Hematology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
  • Sayas MJ; Hematology Department, Gregorio Marañon General University Hospital, Madrid, Spain.
  • Viguria Alegria MC; Hematology Department, Hospital San Pedro Alcántara, Caceres, Spain.
  • Sanchez-Blanco JJ; Hematology Department, Hospital Universitario Dr. Peset, Valencia, Spain.
  • Roig Pellicer M; Hematology Department, Complejo Hospitalario de Navarra, Pamplona, Spain.
  • Luzardo Henriquez HD; Hematology Department, Hospital Morales Messeguer, Murcia, Spain.
  • de Oña R; Hematology Department, Hospital La Fe, Valencia, Spain.
  • Cabezudo ME; Hematology Department, Hospital Dr. Negrín, Las Palmas de Gran Canaria, Spain.
  • Infante MS; Hematology Department, MD Anderson Cancer Center, Madrid, Spain.
  • Queizán Hernández JA; Hematology Department, Hospital de Sant Joan Despí Moisès Broggi, Barcelona, Spain.
  • Sanz-Pamplona R; Hematology Department, Hospital Infanta Leonor, Madrid, Spain.
  • Blanco O; Hematology Department, Hospital General de Segovia, Segovia, Spain.
  • Mozos A; Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology, Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL) and CIBERESP, Barcelona, Spain.
  • Climent F; Pathology Department, Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.
  • Piris MA; Pathology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Am J Hematol ; 98(6): E134-E138, 2023 06.
Article em En | MEDLINE | ID: mdl-36882876
ABSTRACT
(A) Correlation matrix of unsupervised co-regulated genes, based on the 208 genes included in the NanoString platform. Some of the clusters of co-regulated genes corresponded to the following Inflammatory cells; Epstein-Barr virus; B-cells; Cytotoxic T-cells; T-cells; and Proliferation. (B) Analysis of genomic alterations by targeted sequencing. Distribution of mutations in the 62 analyzed genes. Rows correspond to sequenced genes, columns represent individual patients. Color coding green, missense; blue, synonymous; pink, frameshift; violet, Indel; red, stop gained; yellow, UTR.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Vírus Epstein-Barr / Linfoma Extranodal de Células T-NK Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Vírus Epstein-Barr / Linfoma Extranodal de Células T-NK Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article