Combined disruption of T cell inflammatory regulators Regnase-1 and Roquin-1 enhances antitumor activity of engineered human T cells.

Mai, David; Johnson, Omar; Reff, Jordan; Fan, Ting-Jia; Scholler, John; Sheppard, Neil C; June, Carl H

Mai, David; Johnson, Omar; Reff, Jordan; Fan, Ting-Jia; Scholler, John; Sheppard, Neil C; June, Carl H.

Afiliação

Mai D; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104.
Johnson O; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Reff J; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Fan TJ; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Scholler J; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Sheppard NC; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
June CH; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.

Proc Natl Acad Sci U S A ; 120(12): e2218632120, 2023 03 21.

Article em En | MEDLINE | ID: mdl-36920923

Assuntos

Endorribonucleases; Linfócitos T; Humanos; Camundongos; Animais; Citocinas; Ribonucleases/genética

Palavras-chave

T cell therapy; gene editing; inflammation; solid tumors

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T / Endorribonucleases Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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