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Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERRγ Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach.
Somsen, Bente A; Schellekens, Rick J C; Verhoef, Carlo J A; Arkin, Michelle R; Ottmann, Christian; Cossar, Peter J; Brunsveld, Luc.
Afiliação
  • Somsen BA; Laboratory of Chemical Biology, Department of Biomedical Engineering, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
  • Schellekens RJC; Laboratory of Chemical Biology, Department of Biomedical Engineering, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
  • Verhoef CJA; Laboratory of Chemical Biology, Department of Biomedical Engineering, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
  • Arkin MR; Department of Pharmaceutical Chemistry and Small Molecule Discovery Centre (SMDC), University of California, San Francisco, California 94143, United States.
  • Ottmann C; Laboratory of Chemical Biology, Department of Biomedical Engineering, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
  • Cossar PJ; Laboratory of Chemical Biology, Department of Biomedical Engineering, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
  • Brunsveld L; Laboratory of Chemical Biology, Department of Biomedical Engineering, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
J Am Chem Soc ; 145(12): 6741-6752, 2023 03 29.
Article em En | MEDLINE | ID: mdl-36926879

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Estrogênio / Descoberta de Drogas Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Estrogênio / Descoberta de Drogas Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article