Your browser doesn't support javascript.
loading
A gut-secreted peptide suppresses arousability from sleep.
Titos, Iris; Juginovic, Alen; Vaccaro, Alexandra; Nambara, Keishi; Gorelik, Pavel; Mazor, Ofer; Rogulja, Dragana.
Afiliação
  • Titos I; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Juginovic A; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Vaccaro A; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Nambara K; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Gorelik P; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Mazor O; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Rogulja D; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: dragana_rogulja@hms.harvard.edu.
Cell ; 186(7): 1382-1397.e21, 2023 03 30.
Article em En | MEDLINE | ID: mdl-36958331
Suppressing sensory arousal is critical for sleep, with deeper sleep requiring stronger sensory suppression. The mechanisms that enable sleeping animals to largely ignore their surroundings are not well understood. We show that the responsiveness of sleeping flies and mice to mechanical vibrations is better suppressed when the diet is protein rich. In flies, we describe a signaling pathway through which information about ingested proteins is conveyed from the gut to the brain to help suppress arousability. Higher protein concentration in the gut leads to increased activity of enteroendocrine cells that release the peptide CCHa1. CCHa1 signals to a small group of dopamine neurons in the brain to modulate their activity; the dopaminergic activity regulates the behavioral responsiveness of animals to vibrations. The CCHa1 pathway and dietary proteins do not influence responsiveness to all sensory inputs, showing that during sleep, different information streams can be gated through independent mechanisms.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nível de Alerta / Sono Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nível de Alerta / Sono Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article