Predicting the Effect of Renal Function on Systemic Clearance: Is a Simple Scaling Method Sufficient?

McNamara, Patrick J; Meiman, Darius

McNamara, Patrick J; Meiman, Darius.

Afiliação

McNamara PJ; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone, 361. Lexington, Kentucky 40536-0596, USA. Electronic address: pmcnamar@email.uky.edu.
Meiman D; Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

J Pharm Sci ; 112(6): 1724-1732, 2023 06.

Article em En | MEDLINE | ID: mdl-37023855

Assuntos

Nefropatias; Rim; Humanos; Rim/fisiologia; Nefropatias/tratamento farmacológico; Cinética

Palavras-chave

Clinical pharmacology; Dose adjustments; Drug clearance; Kidney disease; Model-informed drug development; Personalized medicine; Pharmacokinetics; Precision dosing; Renal impairment

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rim / Nefropatias Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google