A High Dose of Calcitriol Inhibits Glycolysis and M2 Macrophage Polarization in the Tumor Microenvironment by Repressing mTOR Activation: in vitro and Molecular Docking Studies.

Munir, Maliha Tabassum; Halim, Sobia Ahsan; Santos, Julianna Maria; Khan, Faizullah; Khan, Ajmal; Rahman, Md Mizanur; Hussain, Fazle; Al-Harrasi, Ahmed; Gollahon, Lauren S; Rahman, Shaikh Mizanoor

Munir, Maliha Tabassum; Halim, Sobia Ahsan; Santos, Julianna Maria; Khan, Faizullah; Khan, Ajmal; Rahman, Md Mizanur; Hussain, Fazle; Al-Harrasi, Ahmed; Gollahon, Lauren S; Rahman, Shaikh Mizanoor.

Afiliação

Munir MT; Nutritional Sciences, Texas Tech University, Lubbock, TX, USA.
Halim SA; Obesity and Cancer Biology Lab, Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, Sultanate of Oman.
Santos JM; Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Khan F; Obesity and Cancer Biology Lab, Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, Sultanate of Oman.
Khan A; Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan, Khyber, Pakhtunkhwa, Pakistan.
Rahman MM; Obesity and Cancer Biology Lab, Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, Sultanate of Oman.
Hussain F; Biology Program, Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha, Qatar.
Al-Harrasi A; Mechanical Engineering, Texas Tech University, Lubbock, TX , USA.
Gollahon LS; Obesity and Cancer Biology Lab, Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, Sultanate of Oman.
Rahman SM; Nutritional Sciences, Texas Tech University, Lubbock, TX, USA.

Cell Physiol Biochem ; 57(2): 105-122, 2023 Apr 12.

Article em En | MEDLINE | ID: mdl-37052042

Assuntos

Neoplasias da Mama; Calcitriol; Humanos; Feminino; Calcitriol/farmacologia; Calcitriol/uso terapêutico; Transportador de Glucose Tipo 1/genética; Transportador de Glucose Tipo 1/metabolismo; Simulação de Acoplamento Molecular; Microambiente Tumoral/genética; Serina-Treonina Quinases TOR/metabolismo; Macrófagos/metabolismo; Neoplasias da Mama/patologia; Alvo Mecanístico do Complexo 1 de Rapamicina/metabolismo; Glicólise; Proliferação de Células/genética; Linhagem Celular Tumoral; Ativação de Macrófagos

Palavras-chave

Calcitriol; Tumor microenvironment; Macrophage polarization; Glycolysis; Apoptosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Calcitriol Limite: Female / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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