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Prostaglandin E2/EP4 axis is upregulated in Spondyloarthritis and contributes to radiographic progression.
Mauro, Daniele; Srinath, Archita; Guggino, Giuliana; Nicolaidou, Vicky; Raimondo, Stefania; Ellis, Jonathan J; Whyte, Jessica; Nicoletti, Maria Maddalena; Romano, Marco; Kenna, Tony John; Cañete, Juan D; Alessandro, Riccardo; Rizzo, Aroldo; Brown, Matthew Arthur; Horwood, Nicole J; Haroon, Nigil; Ciccia, Francesco.
Afiliação
  • Mauro D; Rheumatology Unit, Department of Precision Medicine, Università degli Studi della Campania "L. Vanvitelli", Naples, Italy.
  • Srinath A; Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
  • Guggino G; Rheumatology Section, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Italy.
  • Nicolaidou V; Department of Life Sciences, School of Life and Health Sciences, University of Nicosia, Cyprus.
  • Raimondo S; Dipartimento di Biomedicina, Neuroscienze e Diagnostica Avanzata, Università degli Studi di Palermo, Palermo, Italy.
  • Ellis JJ; Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, Queensland, Australia.
  • Whyte J; Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, Queensland, Australia.
  • Nicoletti MM; Rheumatology Unit, Department of Precision Medicine, Università degli Studi della Campania "L. Vanvitelli", Naples, Italy.
  • Romano M; Hepato-Gastroenterology Unit, Department of Precision Medicine, Università degli Studi della Campania "L. Vanvitelli", Naples, Italy.
  • Kenna TJ; Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, Queensland, Australia.
  • Cañete JD; Department of Rheumatology, Hospital Clinic of Barcelona, 08036 Barcelona, Spain.
  • Alessandro R; Dipartimento di Biomedicina, Neuroscienze e Diagnostica Avanzata, Università degli Studi di Palermo, Palermo, Italy.
  • Rizzo A; Dipartimento di Oncoematologia, Sezione di Anatomia Patologica, Azienda Ospedaliera Ospedali riuniti Villa Sofia Cervello, Palermo, Italy.
  • Brown MA; Department of Medical and Molecular Genetics, King's College London, London, UK.
  • Horwood NJ; Norwich Medical School, University of East Anglia, Norwich, UK.
  • Haroon N; Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada. Electronic address: nigil.haroon@uhn.ca.
  • Ciccia F; Rheumatology Unit, Department of Precision Medicine, Università degli Studi della Campania "L. Vanvitelli", Naples, Italy. Electronic address: francesco.ciccia@unicampania.it.
Clin Immunol ; 251: 109332, 2023 06.
Article em En | MEDLINE | ID: mdl-37075950
ABSTRACT
Ankylosing spondylitis (AS) is an inflammatory disease leading to spine ankylosis; however, the mechanisms behind new bone formation are still not fully understood. Single Nucleotide Polymorphisms (SNPs) in PTGER4, encoding for the receptor EP4 of prostaglandin E2 (PGE2), are associated with AS. Since the PGE2-EP4 axis participates in inflammation and bone metabolism, this work aims at investigating the influence of the prostaglandin-E2 axis on radiographic progression in AS. In 185 AS (97 progressors), baseline serum PGE2 predicted progression, and PTGER4 SNP rs6896969 was more frequent in progressors. Increased EP4/PTGER4 expression was observed in AS circulating immune cells, synovial tissue, and bone marrow. CD14highEP4 + cells frequency correlated with disease activity, and when monocytes were cocultured with mesenchymal stem cells, the PGE2/EP4 axis induced bone formation. In conclusion, the Prostaglandin E2 axis is involved in bone remodelling and may contribute to the radiographic progression in AS due to genetic and environmental upregulation.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Espondilite Anquilosante / Dinoprostona Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Espondilite Anquilosante / Dinoprostona Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article