Coordinated prospective follow-up of Lynch syndrome is able to detect the majority of incident cancers.
Dig Liver Dis
; 55(12): 1735-1741, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-37098454
ABSTRACT
BACKGROUND:
Lynch syndrome is one of the most common genetic predispositions to many cancers, most of which do not have a consensus recommendation for screening.AIMS:
We studied in our region the value of a systematized and coordinated follow-up program for patients with Lynch syndrome on all organs at risk.METHODS:
A multicenter prospective cohort evaluation was performed, from January 2016 to June 2021.RESULTS:
One hundred and seventy-eight patients were prospectively included (104 women (58%), median age 44 years, range 35-56 years) with a median follow-up of 4 years (range 2.5-5 years), corresponding to a total of 652 patient-years. The overall cancer incidence rate was 13.80 per 1000 patient-years. Seven of nine cancers (78%) were detected during the follow-up program, with all cancers identified at an early stage. The detection rate of adenomas during colonoscopies was 24%.CONCLUSION:
These preliminary data suggest that coordinated prospective follow-up of Lynch syndrome is capable of detecting the majority of incident cancers, particularly for locations not covered by an international follow-up recommendation. However, these results need to be confirmed by larger-scale studies.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais Hereditárias sem Polipose
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Adenoma
Tipo de estudo:
Clinical_trials
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Middle aged
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article