MicroRNA-19b-3p dysfunction of mesenchymal stem cell-derived exosomes from patients with abdominal aortic aneurysm impairs therapeutic efficacy.

Zhang, Yuxiao; Huang, Xiaoran; Sun, Tucheng; Shi, Linli; Liu, Baojuan; Hong, Yimei; Fu, Qing-Ling; Zhang, Yuelin; Li, Xin

Zhang, Yuxiao; Huang, Xiaoran; Sun, Tucheng; Shi, Linli; Liu, Baojuan; Hong, Yimei; Fu, Qing-Ling; Zhang, Yuelin; Li, Xin.

Afiliação

Zhang Y; School of Medicine, South China University of Technology, Guangzhou, China.
Huang X; Department of Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China.
Sun T; Department of Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China.
Shi L; Department of Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China.
Liu B; Department of Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China.
Hong Y; Department of Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China.
Fu QL; Department of Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China.
Zhang Y; Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Li X; Department of Emergency Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China. zhangyuelin1999@163.com.

J Nanobiotechnology ; 21(1): 135, 2023 Apr 26.

Article em En | MEDLINE | ID: mdl-37101174

Assuntos

Aneurisma da Aorta Abdominal; Exossomos; Células-Tronco Mesenquimais; MicroRNAs; Animais; Camundongos; Aneurisma da Aorta Abdominal/genética; Aneurisma da Aorta Abdominal/metabolismo; Aneurisma da Aorta Abdominal/patologia; Apolipoproteínas E/genética; Apolipoproteínas E/metabolismo; Exossomos/metabolismo; Mamíferos/genética; Mamíferos/metabolismo; Células-Tronco Mesenquimais/metabolismo; Camundongos Knockout para ApoE; MicroRNAs/genética; MicroRNAs/metabolismo; Humanos

Palavras-chave

Abdominal aortic aneurysm; Exosomes; Mesenchymal stem cells; Senescence; Vascular smooth muscle cells

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aneurisma da Aorta Abdominal / MicroRNAs / Exossomos / Células-Tronco Mesenquimais Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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