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Differential dynamics of peripheral immune responses to acute SARS-CoV-2 infection in older adults.
Lewis, Sloan A; Sureshchandra, Suhas; Zulu, Michael Z; Doratt, Brianna; Jankeel, Allen; Ibraim, Izabela Coimbra; Pinski, Amanda N; Rhoades, Nicholas S; Curtis, Micaila; Jiang, Xiwen; Tifrea, Delia; Zaldivar, Frank; Shen, Weining; Edwards, Robert A; Chow, Daniel; Cooper, Dan; Amin, Alpesh; Messaoudi, Ilhem.
Afiliação
  • Lewis SA; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.
  • Sureshchandra S; Institute for Immunology, University of California, Irvine, Irvine, CA, USA.
  • Zulu MZ; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.
  • Doratt B; Institute for Immunology, University of California, Irvine, Irvine, CA, USA.
  • Jankeel A; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.
  • Ibraim IC; Institute for Immunology, University of California, Irvine, Irvine, CA, USA.
  • Pinski AN; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.
  • Rhoades NS; Institute for Immunology, University of California, Irvine, Irvine, CA, USA.
  • Curtis M; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.
  • Jiang X; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.
  • Tifrea D; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.
  • Zaldivar F; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.
  • Shen W; Institute for Immunology, University of California, Irvine, Irvine, CA, USA.
  • Edwards RA; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.
  • Chow D; Department of Statistics, University of California, Irvine, Irvine, CA, USA.
  • Cooper D; Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA.
  • Amin A; Institute for Clinical and Translational Science, University of California, Irvine, Irvine, CA, USA.
  • Messaoudi I; Department of Statistics, University of California, Irvine, Irvine, CA, USA.
Nat Aging ; 1(11): 1038-1052, 2021 11.
Article em En | MEDLINE | ID: mdl-37118336
ABSTRACT
In this study, peripheral blood mononuclear cells from young and old patients with COVID-19 were examined phenotypically, transcriptionally and functionally to reveal age-, time- and severity-specific adaptations. Gene signatures within memory B cells and plasmablasts correlated with reduced frequency of antigen-specific B cells and neutralizing antibodies in older patients with severe COVID-19. Moreover, these patients exhibited exacerbated T cell lymphopenia, which correlated with lower plasma interleukin-2, and diminished antigen-specific T cell responses. Single-cell RNA sequencing revealed augmented signatures of activation, exhaustion, cytotoxicity and type I interferon signaling in memory T and natural killer cells with age. Although cytokine storm was evident in both age groups, older individuals exhibited elevated levels of myeloid cell recruiting factors. Furthermore, we observed redistribution of monocyte and dendritic cell subsets and emergence of a suppressive phenotype with severe disease, which was reversed only in young patients over time. This analysis provides new insights into the impact of aging on COVID-19.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucócitos Mononucleares / COVID-19 Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucócitos Mononucleares / COVID-19 Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article