Characterizing Olfactory Dysfunction in Patients with Unilateral Cleft Lip Nasal Deformities.
Facial Plast Surg Aesthet Med
; 25(6): 457-465, 2023.
Article
em En
| MEDLINE
| ID: mdl-37130297
ABSTRACT
Background:
Unilateral cleft lip nasal deformity (uCLND) is associated with olfactory dysfunction, but the underlying etiology remains poorly understood.Objective:
To investigate the etiology of uCLND-associated olfactory dysfunction using clinical, computational, and histologic assessments.Methods:
Inclusion criteria uCLND patients >16 years undergoing septorhinoplasty. Exclusion criteria prior septoplasty or rhinoplasty, pregnancy, sinusitis. Measuredoutcomes:
patient-reported scores, rhinomanometry, smell identification and threshold tests, computational fluid dynamics (CFD) airflow simulations, and histologic analysis of olfactory epithelium.Results:
Five uCLND subjects were included 18-23 years, three male and two female, four left-sided cleft and one right-sided cleft. All subjects reported moderate to severe nasal obstruction. Smell identification and threshold tests showed varying degrees of hyposmia. Nasal resistance was higher on the cleft side versus noncleft side measured by rhinomanometry (median 3.85 Pa-s/mL, interquartile range [IQR] = 21.96, versus 0.90 Pa-s/mL, IQR = 5.17) and CFD (median 1.04 Pa-s/mL, IQR = 0.94 vs. 0.11 Pa-s/mL, IQR = 0.12). Unilateral olfaction varied widely and was dependent on unilateral percentage olfactory airflow. Biopsies revealed intact olfactory neuroepithelium.Conclusions:
uCLND-associated olfactory dysfunction appears to be primarily conductive in etiology and highly susceptible to variations in nasal anatomy. Clinical Trial Registration number NCT04150783.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Obstrução Nasal
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Fenda Labial
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Transtornos do Olfato
Tipo de estudo:
Prognostic_studies
Limite:
Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article